Krebsstatistik

**Prof. Wust** · 25.10.2001, 21:18

RE: Krebsstatistik

Die meisten Untersuchungen beziehen sich auf das Risiko der stillenden Mutter, an einem Mammakarzinom zu erkranken. Da ist der protektive Effekt des Stillens bekannt. Anders sieht es bei den Kindern aus. Ich habe einige Untersuchungen in Medline gefunden (s.u.), die, wie Sie sehen, mehrdeutige Ergebnisse liefern. Groß wird der Effekt nicht sein, wenn überhaupt vorhanden.

Being breastfed in infancy and breast cancer incidence in adult life: results from the two nurses' health studies.
AU: Michels,-K; Trichopoulos,-D; Rosner,-B; Hunter,-D; Colditz,-G; Hankinson,-S; Speizer,-F; Willett,-W
AD: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. [email protected]

IS: 0002-9262
PY: 2001
LA: English
CP: United-States
AB: Events during perinatal and early life may influence the incidence of breast cancer in adult life, and some case-control studies suggest that having been breastfed may reduce breast cancer risk. The authors studied this association among premenopausal and postmenopausal women by using data from the two Nurses' Health Studies, the Nurses' Health Study (using data from 1992 to 1996) and the Nurses' Health Study II (using data from 1991 to 1997). A history of being breastfed was self-reported by the study participants. During a total of 695,655 person-years, 1,073 cases of invasive breast cancer were diagnosed. The authors did not observe any important overall association between having been breastfed and the development of breast cancer later in life among premenopausal women (covariate-adjusted relative risk = 0.97, 95% confidence interval (CI): 0.78, 1.20) or postmenopausal women (covariate-adjusted relative risk = 1.12, 95% CI: 0.92, 1.37). No significant trend was observed with increasing duration of breastfeeding. The authors also used data on breastfeeding retrospectively collected from 2,103 mothers of participants of the two Nurses' Health Studies. With the mothers' reports, the covariate-adjusted odds ratio of breast cancer was 1.11 (95% CI: 0.88, 1.39) for women who were breastfed compared with those who were not. Data from these two large cohorts do not support the hypothesis that being breastfed confers protection against subsequent breast cancer.

Breast-feeding duration and the risk of malignant diseases in childhood in Sweden.
AU: Hardell,-L; Dreifaldt,-A-C
AD: Department of Oncology, Orebro Medical Center, Sweden. [email protected]
SO: Eur-J-Clin-Nutr. 2001 Mar; 55(3): 179-85
IS: 0954-3007
PY: 2001
LA: English
CP: England
AB: OBJECTIVE: To evaluate childhood cancer in relation to duration of breast-feeding. SETTING: Sweden. Records from Child Healthcare Centres were scrutinised regarding information on breast-feeding and other health-related items. SUBJECTS: All children aged 0-14 y with a malignant disease (benign brain tumours included) during the time period 1988-91 (n = 962) were identified from the Swedish Cancer Register. An equal number of controls matched for sex and age were selected from the Swedish Birth Register. RESULTS: Information was obtained for 835 cases and 860 controls. Overall, duration of breast-feeding did not influence the risk for a malignant disease in this age group. However, breast-feeding > or = 1 month increased the risk for non-Hodgkin's lymphoma (NHL) yielding an odds ratio (OR) 5.5 with 95% confidence interval (CI) 1.2-25. Breast-feeding 1 -< 6 months gave OR 5.1, CI 1.1-24 and > 6 months gave OR 7.0, CI 1.3-37 with a significant trend (P = 0.04). Adjustment for maternal and birth-related co-variates gave similar results. For other malignancies no significant changes of the risk were obtained. CONCLUSIONS: Overall, no association between duration of breast-feeding and childhood malignancies was found except for a significantly increased risk for NHL, but this was based on low numbers of cases and needs to be confirmed in other investigations.
MESH: *Breast-Feeding-adverse-effects; *Lymphoma,-Non-Hodgkin-epidemiology; *Neoplasms-epidemiology
MESH: Adolescence-; Brain-Neoplasms-epidemiology; Brain-Neoplasms-etiology; Case-Control-Studies; Child-; Child,-Preschool; Infant-; Infant,-Newborn; Lymphoma,-Non-Hodgkin-etiology; Neoplasms-etiology; Odds-Ratio; Registries-; Risk-Factors; Sweden-epidemiology; Time-Factors
959-8049
PY: 2001
LA: English
CP: England
AB: The role of breast-feeding in protecting against childhood acute leukaemia and lymphomas is uncertain. We investigated this issue in a case-control study comprising 117 patients, aged 2-14 years, with acute lymphocytic leukaemia (ALL), Hodgkin's (HL) and non-Hodgkin's lymphoma (NHL), as well as 117 controls matched for age, sex and ethnicity. Information was collected via a telephone interview of the mothers. The median duration of breast-feeding among patients was significantly shorter than among controls, 7 (range 0-23) and 10 (range 0-20) months, respectively (P<0.0001). Breast-feeding of 0-6 months' duration, when compared with feeding of longer than 6 months, was associated with increased odds ratios (OR) for ALL (OR=2.47, 95% confidence interval (CI) 1.17-5.25), HL (OR=3.75, 95% CI 0.80-18.69), NHL (OR=4.06, 95% CI 0.82-22.59), and overall (OR=2.79, 95% CI 1.54-5.05). In the patient group, there were a significantly higher number of children and people per family, and patients were of a higher birth order than controls. In multivariate analysis, breast-feeding duration continues to be an independent predictor of lymphoid malignancies (P=0.015). In conclusion, breast-feeding lasting longer than 6 months may protect against childhood acute leukaemia and lymphomas.
CM: Comment In: Eur J Cancer. 2001 Jan;37(2):155-8 21094758
MESH: *Breast-Feeding; *Hodgkin-Disease-prevention-and-control; *Leukemia,-Lymphocytic,-Acute-prevention-and-control; *Lymphoma,-Non-Hodgkin-prevention-and-control
MESH: Adolescence-; Case-Control-Studies; Child-; Child,-Preschool; Time-Factors
TG: Female; Human; Male
PT: Journal-Article
SH: prevention-and-control
SB: Index-Medicus
UD: 20010329

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